Formation of Itraconazole–Succinic Acid Cocrystals by Gas Antisolvent Cocrystallization

‏‎suppression of coke formation in thermal cracking by coke inhibitors‎‏

‏‎the main purpose of this research was to:1.develop a coking model for thermal cracking of naphtha.2.study coke inhibition methods using different coke inhibitors.developing a coking model in naphtha cracking reactors requires a suitable model of the thermal cracking reactor based on a reliable kinetic model.to obtain reliable results all these models shall be solved simultaneously.for this pu...

Cocrystallization in Nutraceuticals

Towards a Rigorous Solution of Population Balance Equations for the Gas Antisolvent Crystallization (GAS) Process

The utilization of SCFs for the processing of several products has attracted considerable interest in recent years as an emerging “green” technology. Particle formation using SCFs can be carried out according to several different techniques, including antisolvent techniques such as the gas-antisolvent (GAS) process. The potential advantages of the GAS crystallization process lies in the possibi...

A Comparative Theoretical Study of Picric Acid and Its Cocrystals

A novel cocrystal of picric acid/acetophenone was prepared by solvent evaporation method and the crystal structure was characterized by single crystal X-ray diffraction. Analysis of the crystal structure shows that the hydrogen bonding, van der Waals and π-π stacking are the main driving forces for the cocrystal formation. Density functional theory (DFT) calculation was performed to better unde...

Phase Transformation of Adefovir Dipivoxil/Succinic Acid Cocrystals Regulated by Polymeric Additives

The polymorphic phase transformation in the cocrystallization of adefovir dipivoxil (AD) and succinic acid (SUC) was investigated. Inspired by biological and biomimetic crystallization, polymeric additives were utilized to control the phase transformation. With addition of poly(acrylic acid), the metastable phase newly identified through the analysis of X-ray diffraction was clearly isolated fr...